Appreciated!!! My Aussie/Pyrenees mix has had no issues with it, for instance. I like Frank so much that I had to give him his own story. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. Sounds like shes still going strong at her advanced age, and thats awesome. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Im hoping to get a Smoothie myself in the future. It was winter. -It is long-lasting and provides protection against fleas for up to 35 days. Thanks for reply. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. I found a paper on the web written with credits to several vets. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Thanks for your informative article. Simparica is administered once a month as a flavored chewable. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. First, I want to thank you for the time and effort that went into writing this article. Unacceptable for me) He is MDR1 clear. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. , Emily, thanks for a very helpful and informative article. Thanks. Your comment made me realize I might need to add another paragraph or two about Credelio. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Im glad you found it helpful. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Evoluciona. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Trish. What do you know about this? Thank you for bringing this to my attention! If you think about it, come back here and let me and other readers know what worked best for you! In summary, use with caution. IMPORTANT SAFETY INFORMATION: NexGard is for use in . Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. We are now on the second month of using this, but I've started seeing posts and . My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. I hate to use anything, but also tired of keeping my dogs in a bubble. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. My vet wants to give him a vaccine (?) Theyre so fun and crazy at that age. I tried Seresto with my girl and she had a seizure. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. Tap to zoom. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. I gave a mini aussie and a minnie aussie/border collie mix. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. After logging in you can close it and return to this page. I had never heard of Dimmitrol before, but I did some research after reading your comment. They said Frontline Plus doesnt really work anymore like it used too. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. My other vet never brought this up when discussing my MAS. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Oh no! Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Is Simparica Trio safe for dogs with MDR1? However, as with any chemical compounds, caution is advised even with products deemed to be safe. Im leaning toward Frontline Plus based on what you wrote. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. (There are other places, but none more affordable that Ive found.) And each monthly chewable tablet has a palatable liver . So glad you found this useful! Do you know what the ingredients are in the medicated shampoo? Is Simparica safe for MDR1 dogs? Unless youre, say, an expat living in China, you can definitely find a better option. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. Key Features of Simparica Trio. This gave me a great start for research. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. $161.99. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. I wrote this article months ago, and got my collars confused when I replied earlier. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica Trio 11.1-22 lbs. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Simparica Trio is proven to kill 5 species of ticks. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. The tail curling and pacing lasted over a week. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. GestorVet es el futuro de la gestin veterinaria. As with everything else, monitor your dog for symptoms. Thank you for all your research and article!! Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. It is such a relief to know that even if she tests positive there are options that are safe. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. Second, Id like to ask a question if you dont mind. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Is Frontline Plus still safe? Interceptor is the go-to heartworm preventive for many Collie parents. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Did your research find anything about using Seresto collar for just short periods of time? Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Please keep me updated if you think of it! The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Safe in avermectin-sensitive collies and dogs with the MDR1 gene; I disagree. Great summary! They were extremely helpful people. Hi Emily, do you know if panacure is a safe wormer? This year she has a very high degree of irritation when applied (I had to wash it off). Thanks. Would this be your recommendation? You should still keep an eye on your pet when introducing new organic products. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Somewhere I read that its good for 4 kinds. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. 1,9 And the fact is, dogs love both chews. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. Is this true? 1 x 40mg tablet for 22.1 to 44 pounds. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) (Which made him feel really sick.) Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Selamectin is their shared main ingredient. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. After her first heat she went into a false pregnancy. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Is this vaccine something youve heard of? 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