I had to give him flea prevention because he goes to Daycare. He scratched at them which made it worse. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. My dog was HEALTHY and HAPPY prior to giving him this drug and literally days later he is struggling to recover. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. Im convinced the medicine caused this and now she cant walk. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). Idk what to do. well my lola went into labor xmas day. corgi lying in grass next to woman's feet. Is it effective? So here we are on the 2nd dose. Trifexis and Simparica are available only with a prescription from your veterinarian. But you can use a collar or topical for ticks if needed. They want another blood draw in 3 weeks to see where she is. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. I could never forgive myself. I regret putting her on this drug. A week after I lost her I got COVID and was in the hospital for 20 days. Mine was given the medication 9 days ago. Strictly natural with zero side effects from now on. This morning was the first morning he left water in his bowl. I hope this drug has not caused permanent damage. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Then I saw this and realized. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. Update June 7th. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. Last year I gave them this but didn't notice any issues. This past October he just wasn't the same. Back to the vet and I hope they credit my money. She became extremely lethargic and feverish so we rushed her to Hospital. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. Has anyone experienced cardiac issues while under anesthesia on this medication? Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. and now i'm on an hour by hour let's see if she will perk up. I'm so sorry. Tremors continued, on and off, for 2 hours. I will never give him this drug again. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. We go for more bloodwork today and are praying for better news. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. I dont know. I am so mad at myself and so upset that I am the one that has made him sick. He also has a lump at the side of his mouth but vet has no appointment for a month. He eats and drinks fine but looks like we havent fed him in days. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. I wish every one the best. I wish I could get this out of her system now. What You Need to Know About the Lyme Vaccine for Dogs. He has been drinking more water then usual. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. Shame on you! Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). The costs associated with these two products are roughly the same. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Anything I can do for him? Saturday he started up the drinking again and threw up his breakfast. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. I am also very worried about him. She had terrible watery diarrhea and is not interested in eating. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Her last dose of Simparica Trio was given to her on October 1, 2021. On Jan 4th for the first time. Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. He is a 6 month old Bloodhound so they are always hyper. What are the side effects of simparica trio for dogs? So sorry to hear, and good for you in recognizing the problem! Reading your comments, this drug may be the cause. Sunday, he was lethargic and refused to eat. My vet recommended the tablet to save on monthly costs for flea and tick treatment. Do you have a homeopathic vet in your area? I have every intention of calling and filing a complaint. The cardiologist found no heart condition that would cause this. 10 days after taking Simparica, she started having muscle tremors. Initially I noticed minor tremors and twitching when he slept or was just relaxing. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. I have reached out to the company but one email bounced and the other was an online form. Over two weeks later she still can not walk properly. (145 Reviews) $15.50 - $31.09. , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. I'm so upset. Side effects The contra indication is important to know before you utilize the simparica. He's been in an emergency hospital for two nights, no signs of improvement despite blood transfusions and other symptoms. She has been very unpredictable and snapping at people but this is improving. Poor dog prob thinks HE did something wrong. He collapsed & went limp in my arms . I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. Did you go to the vets or not? This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. We had family in for the weekend and he was not himself. Something I will never know what happened to herIf I knew this would kill her I would never had used it. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. The next day she had diarrhea. The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. And now I'm upset with myself for giving this to my dog without doing research. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. After reading all these posts that sound so similar to what we are going through. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. this is how Simparica works on insects who bite your dog. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. Itching has decreased immensely. This medication is given once a month by mouth, with or without food. My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. Refused to eat the rice and sweet potato I made for him last night. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. I have ordered what I normally use and will throw this in the trash! According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. I have had German Shepherds for 40 yrs. Bravecto has six topical solutions for dogs by weight/size. My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. Humans are another matter. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. Use topical or a collar if you are concerned. I'm at a loss We had same issues. Read the package insert and it does list tremors and seizures as a side effect. In total we spend around $780 trying to control/stop the tremors & seizures. Advised I could call Simparica for reimbursement or to report side effects. My other two dogs had a little loose stool but nothing else. It can also cause seizures and tremors, but those side effects are incredibly rare. We rushed to the vets who said it had to be neurological and once I mentioned the diarrhea she looked into Simparica suspecting MDR1 with my dog. Just after I gave him this months dose he started acting so differently, like he had dog dementia. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. So bad that the FDA made them put a huge warning now on the package. Very common in: Dogs of any age, breed, or gender can experience vomiting. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. Simparica is pretty new in England and it seems they are trialling it. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. I don't know if the lump came from it or something else. Thanks all for sharing your experiences. My husband said , get dressed were taking him in . GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Please think these things through before subjecting your pet to internal insecticides. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. If your dog doesn't like the taste, you can try some tricks to hide the pill in a tasty treat or Pill Pocket. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. He is back to his old self now but we will never give him this medication again. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. Or has it been too many doses ? How do I get this out of his system and what are you using instead? Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. I sure hope we don't have ongoing problems. I took him to the ER they checked his vitals and sent me home. Its hard to say since he has previously been diagnosed with lymes. If fact it specifically states on the product label "Not for use in humans". He was in excellent health prior to this incident. The vet suggested this medication for my 9+ yr old English Bulldog. I will do anything to stop this from hurting or killing anyone else's baby. Our golden retriever had his first seizure after taking Simparica Trio last October. This stuff should be banned. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Will not be using this treatment again!!! It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. Somedays he will have 2 and then he will go for a couple days without having any issues. That evening after giving it to him he has puked various times. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. The following day he would not even drink water. . I finally got him to eat some chicken and he threw that up 2 hours later. Our boy Axel had been on Heartgard his entire life. I am so incredibly upset with myself for trusting my vet and giving my dog this product. She has had tremors, very lethargic, drinking lots of water. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. What Are The Side Effects Of Simparica Trio For Dogs? Billy Boy is a 9 week old Daisy Dog. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. Head down, tail down, will stand in a corner and stare at the wall. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. He had full wellness exam three ago and was in perfect shape. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Side effects are uncommon, but may occur in some cases. I hope we get to the bottom of it as this is not fun. gave this to my dog three different times. Thank you all so much for this thread and giving me hope. Does this sound familiar to anyone? I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. Hoping for good news with your pup!! I do know that she was a healthy and somewhat energetic 10 year old before the treatment. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. I would notice he gets super tired walking and would go limp in my arms. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. Vet put her on metronidazole which is working. Hopefully there are many other dogs that are unaffected, and just aren't written about here. 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